Polyamino Acids for Drug Delivery Application

CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has announced the launch of its new line of Polyamino Acids for the research community, including the mPEG-PCL-PLG, mPEG-PLGA-PGA, and PCL-b-PASP. These new polymers are designed to provide a more versatile and effective way for scientists working in the field of drug delivery. Poly(amino acids) are naturally occurring biocompatible and biodegradable synthetic linear polymers composed of amino acids as monomeric units. These polymers mainly contain the poly(acidic amino acids) (e.g., poly(l-glutamic acid) (PLG) and poly(aspartic acid)), and the poly(basic amino acid) (e.g., polylysine (PLL) and polyarginine). Poly (amino acids) have several potential advantages as biomaterials. A large number of polymers and copolymers can be prepared from various amino acids. Side chains provide sites to attach small peptides, drugs, cross-linking agents, or dangling groups that can be used to modify the physical and mechanical properties of the polymers. Since these polymers release natural amino acids as the major products of polymer backbone cleavage, their degradation products have low systemic toxicity. Extensive research has thus been conducted on the use of poly (amino acids) as functional materials, leading to the development of bioactive peptides that can be used in biological fields such as tissue engineering, regenerative medicine and drug/gene delivery systems. Poly(amino acids) also have significant biological functions such as targeting specificity and easy metabolism of their degradation products. Based on these properties, various poly (amino acid) materials hybridized with synthetic polymers have also been investigated as functional materials. CD Bioparticles now offers researchers worldwide a variety of Polyamino Acids with unique properties and sizes for drug delivery applications, including the mPEG-PCL-PLG, mPEG-PLGA-PGA, mPEG-PLGA-PLL, and PCL-b-PASP.