Particles for Solid Phase Organic Synthesis

With years of experience in the pharmaceutical and life science sectors, CD Bioparticles has announced the expanded portfolio of its new Particles for Solid Phase Organic Synthesis, including functional resins, preloaded resins and resins for special synthesis, providing a more efficient and time-saving method for the synthesis of small molecules, peptides and oligonucleotides. Solid Phase Organic Synthesis (SPOS) is a method in which molecules are covalently attached to a solid support and chemically synthesized stepwise using selective protecting groups. This method offers many significant advantages over conventional solution phase synthesis methods, including purification of the product by simple filtration of the polymer matrix, automation, ease of handling, low moisture susceptibility, minimal side reactions, no need for polymerization due to targeted separation of polymer particles, and recyclability of the polymer matrix for reuse. As a result, the time required for separation is very short and predictable. The traditional support materials are polystyrene (PS)-based resins and polyethylene glycol (PEG)-grafted PS resins. The presence of PEG makes the resins compatible with polar solvents, especially water. SPOS is widely used in organic synthesis, particularly in the field of drug discovery, where efficient synthesis is highly desirable for high-throughput screening and optimization. In addition, with the advent of solid-phase technology, solid-phase peptide synthesis (SPPS) has become a more practical part of scientific research today. CD Bioparticles now offers a range of functional resins and preloaded resins to meet the needs of small molecule, peptide, and oligonucleotide synthesis. Available in a variety of diameters (from 40 µm to 560 µm) and linker types, these SPOS particles offer excellent chemical and mechanical stability, efficient isolation of intermediates, and improved reaction conversions.