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It is essential for healthcare providers to consider potential drug interactions when prescribing Zhewitra 60 Mg. Concomitant use of nitrates, alpha-blockers, certain antifungal agents, and HIV protease inhibitors may potentiate the hypotensive effects of vardenafil, leading to an increased risk of adverse events. Patients should be counselled to disclose their complete medication history to their healthcare provider to mitigate the risk of interactions.